Synthesis and antimalarial activity evaluation of 3-(3-(7-chloroquinolin-4-ylamino)propyl)-1,3-thiazinan-4-one derivatives

Synthesis and antimalarial activity evaluation of 3-(3-(7-chloroquinolin-4-ylamino)propyl)-1,3-thiazinan-4-one derivatives

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Some novel derivatives of Manicure Kit 3-(3-(7-chloroquinolin-4-ylamino)propyl)-1,3-thiazinan-4-one were synthesized and characterized by their physical and spectral data.All the synthesized compounds were subsequently screened for in vitro antimalarial activity against chloroquine sensitive strain of Plasmodium falciparum (RKL-2) employing chloroquine as the reference drug.Most of the synthesized compounds exhibited mild to Pacifiers moderate susceptibilities towards the parasite in comparison to the standard.It was found that antimalarial activity of 3-(3-(7-chloroquinolin-4-ylamino)propyl)-2-(4-bromophenyl)-1,3-thiazinan-4-one was marginally superior than all the compounds evaluated.